The lymphoid-associated interleukin 7 receptor (IL7R) regulates tissue-resident macrophage development
نویسندگان
چکیده
منابع مشابه
PU.1 regulates expression of the interleukin-7 receptor in lymphoid progenitors.
Development of the lymphoid system is dependent on the Ets family transcription factor PU.1. We demonstrate that PU.1(-/-) hematopoietic progenitors fail to express IL-7Ralpha transcripts. Promoter and chromatin crosslinking analyses suggest that PU.1 directly regulates transcription of the IL-7Ralpha gene. Retroviral transduction of IL-7Ralpha into PU.1(-/-) progenitors restores IL-7-dependent...
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Interleukin-7 receptor α (IL7R) is required for normal lymphoid development. Loss-of-function mutations in this gene cause autosomal recessive severe combined immune deficiency. Here, we describe somatic gain-of-function mutations in IL7R in pediatric B and T acute lymphoblastic leukemias. The mutations cause either a serine-to-cysteine substitution at amino acid 185 in the extracellular domain...
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ژورنال
عنوان ژورنال: Development
سال: 2019
ISSN: 1477-9129,0950-1991
DOI: 10.1242/dev.176180